Researchers
University of Pittsburgh Researchers
The University of Pittsburgh has a long history of multidisciplinary
collaboration crossing several divisions, departments, and schools.
Currently, there is a broad range of investigative activities that
focus on geriatrics and gerontology. Some of the investigators, virtually
all of whom are NIH-funded, are listed below along with their area
of expertise:
Howard Aizenstein, MD, PhD: Geriatric Depression
Kathryn Albers, Ph.D: Aging impact on the autonomic nervous system
Robert Arnold, MD: End-of-life care
David Barnard, PhD: Bioethics in end-of-life care
Steven Belle, PhD: Director of National Alzheimer
Disease Research Center (ADRC) Data Center
Nicolaas Bohnen, MD, PhD: Parkinson’s Disease and movement disorders
Robert Bowser, PhD: Neurodegenerative Disease
Bob Branch, PhD: Pharmacologic changes in Cytochrome P450 with age
Meryl Butters, PhD: Geriatric Depression (novel imaging approaches)
Daniel Buysse, MD:Sleep disorders in older adults
Nick Castle, PhD: Quality of care assessment in long-term care
Jane Cauley, PhD: Osteoporosis
Rakié Cham, PhD: Balance and mobility in older adults
Brenda Cole: Spiritual interventions
Kim Coley, PharmD: Clinical outcomes of medication
Rory Cooper, MD: Assistive technology (Director, National Wheelchair
Center)
Hollis Day, MD, MPH: Educational interventions and programs in geriatrics for medical trainees
Howard Degenholtz, PhD: Quality of life assessment in long-term care
William DeGroat, PhD: Neuroscience/neuropharmacology of the lower urinary
tract
Steven T. DeKosky, MD
Anthony Delitto PhD PT: Spinal cord disorders in the aged
Hiroko Dodge, PhD: Cognition and aging
Jackie Dunbar-Jacob, PhD, RN: Medication use and adherence in chronic
disease
Sandra Engberg, PhD, RN, CRNP
Robert Ferrell, PhD
Michael Fine, MD: Pneumonia in the community and nursing home
G. Kelley Fitzgerald , PhD, PT, OCS: Osteoarthritis and knee stability
Andrea Fox, MD: Innovative care models, especially for marginalized
elderly patients
Charles Friedman, PhD: Informatics and aging
Joseph Furman, MD: Aging and vestibular/balance changes
Mary Ganguli, MD, MPH
Robert Goodman, PhD: Community-based geriatric research
Brett Goodpaster, PhD: Sarcopenia
Steven Graham, MD, PhD: Neurogegenerative disease
Susan Greenspan, MD: Osteoporosis
Derek Griffiths, PhD: Cerebral control mechanisms for voiding dysfunction
Martica Hall, PhD: Sleep and aging
Steven Handler, MD: Medication error reduction; informatics to improve care
Susan Hardy, MD, PhD: Resilience in frail elderly
Joe Hanlon, PharmD: Geriatric pharmacotherapy
John Hennon, EdD: Efficacy of geriatric educational programs
Ronald Herberman, MD: Cancer and aging
Rachel Hess, MD: Menopause
John Huard, PhD
Wishwa Kapoor, MD: Syncope; pneumonia
Jordan F. Karp, M.D.
M. Ilyas Kamboth, PhD: Genetics and Alzheimer’s Disease
William Klunk, MD, PhD: Alzheimer's Disease and Aging
Patricia Kroboth, PhD: Benzodiazepines in the elderly
Lewis Kuller, MD: Epidemiology of aging, cardiac disease, and dementia;
prevention
Kent Kwoh, MD, MPH: Osteoarthritis
Judith Lave, PhD
John Lazo, PhD: Alzheimer’s Disease
Iliya Lefterov, MD, PhD: Alzheimer’s Disease
Michael Lewis, PhD
Eric Lenze, MD
Oscar Lopez, MD: Alzheimer’s Disease
Lynn M. Martire, PhD
Judith Tabolt Matthews, PhD, MPH, RN
Karen Matthews, PhD: Social and behavioral aspects of cardiac disease
Carolyn Meltzer, MD: Neuroimaging for neurodegenerative diseases and neuropsychiatric disorders
Timothy Monk, DSc, MD: Sleep and aging
Robert Muder, MD: Pneumonia and urinary tract infections in long term care
Benoit H. Mulsant, MD
David Nace, MD: Infections in long-term care; quality improvement
in long-term care
Robert Nebes, PhD: Cognition in neurodegenerative diseases
Joel Nelson, MD: Prostate cancer
Anne Newman, MD, MPH
Eric Nofzinger, PhD: Sleep in older adults
Trevor Orchard, M.B.B.Ch., M.Med.Sci.: Diabetes in older adults
Harold Pincus, MD: Health care outcomes (Director, RAND Health Pittsburgh)
Bruce Pollock, MD, PhD
Julie Price, PhD: Neurodegenerative diseases and geriatric mood disorders
Mark Redfern, PhD
Neil M. Resnick, MD
Charles Reynolds, III, MD
Eric Rodriguez, MD: Dementia in primary care; medication adherence
Joan C. Rogers, PhD, OTR/L
Daniel Rosen, PhD: Drug abuse in the elderly
Jules Rosen , MD: Nursing home organization and resident care
Michelle Rossi, MD: Polypharmacy in the elderly
Fred Rubin, MD: Delirium
Thomas Rudy, PhD: Chronic pain management and older adults
Judith Saxton, PhD: Neuropsychological changes in aging and dementia
Werner Schaefer, DI: Geriatric urinary incontinence
Stefan Schlatt, PhD: The aging testis
Elizabeth Ann Schlenk, PhD: Physical activity and aging
Karen Schmidt, PhD: Facial expression and movement disorders; psychiartic co-morbidity
Richard Schulz, PhD
Frank Sciurba, MD: Chronic obstructive pulmonary disease
Katherine Shear, MD: Grief and older adults
Myrna Silverman, PhD: Anthropology; racial differences in coping with
chronic disease
Patrick Sparto, PhD, PT: Aging and vestibular disease
Andrew Stewart, MD: Osteoporosis; diabetes (discoverer of PTH-rP)
Stephanie Studenski, MD: Frailty, falls, and dysmobility
Stephen Thomas, PhD: Partnerships for community outreach in aging
Connie Tompkins, PhD
Don Trump, MD: Prostate cancer
Asher Tulsky, MD: Collaborative medicine in Geriatrics and Internal Medicine
Kim Tyrrell, DrPh: Carotid and other peripheral vascular disease in older adults
Kathleen Dobrosielski Vergona, MPH, PhD
Arnold Wald, MD: Geriatric bowel and sphincter dysfunction
Mary Wasko, MD, MSc: Cardiovascular disease in rheumatoid arthritis
Debra K. Weiner, MD: Chronic pain, acupuncture, and related modalities
Ellen Whyte, MD: Geriatric post stroke depression
Rollin Wright, MD: Inappropriate medication use in long term care
Michael Zigmond, PhD: Parkinson’s disease
Joseph Zmuda, PhD: Bone strength and loss
George Zubenko, PhD
Robert Ferrell PhD: Population genetics and evolution
Representative Articles
Dengel DR, Brown MD, Ferrell RE, Reynolds TH 4th, Supiano MA
Exercise-induced changes in insulin action are associated with ACE
gene polymorphisms in older adults
Physiol Genomics, 2002 Oct. 29,11 (2): 73-80
McCole SD, Brown MD, Moore GE, Ferrell RE, Wilund KR, Huberty A, Douglass
LW, Hagberg JM
Antiotensinogen M235T polymorphism associates with exercise hemodynamics
in postmenopausal women
Physiol Genomics, 2002 Aug. 14; 10 (2): 63-9
Sweet RA, Pollock BC, Sukonick Dl, Mulsant BH, Rosen J, Klunk WE,
Kastango KB, DeKosky ST, Ferrell RE
The 5-HTTPR polymorphism confers liability to a combined phenotype
of psychotic and aggressive behavior in Alzheimer disease
Int Psychogeriatric, 2001 Dec.13 (4): 401-9
Mary Ganguli, MD, MPH: Epidemiology
of dementia in older adults
Representative Articles
Chen P, Ratcliff R, Belle SH, Cauley JA, DeKosky ST, Ganguli M.
Patterns of cognitive decline in pre-symptomatic Alzheimer's disease:
a prospective community study
Archives of General Psychiatry, 58: 853-858, 2001
Ganguli M, Dodge HH, Mulsant BH
Rates and predictors of mortality in an aging, rural, community-based
cohort: the role of depression
Archives of General Psychiatry, 59: 1046-1052, 2002.
Dodge HH, Shen C, Pandav R, DeKosky ST, Ganguli M
Functional transitions and active life expectancy associated with Alzheimer's
disease
Archives of Neurology, 60: 253-259, 2003.
John Huard, PhD
Representative Articles
Peng H, Wright V, Usas A, Gearhart B, Shen HC, Cummins J, Huard J
Synergistic enhancement of bone formation and healing by stem cell-expressed
VEGF and bone morphogenetic protein-4
J Clin Invest, 2002 Sept; 110(6):751-9
PMID: 12235106 [PubMed - indexed for MEDLINE]
Li Y, Huard J.
Differentiation of muscle-derived cells into myofibroblasts in injured
skeletal muscle.
Am J Pathol, 2002 Sep;161(3):895-907. PMID: 12213718 [PubMed
- indexed for MEDLINE]
Qu-Petersen Z, Deasy B, Jankowski R, Ikezawa M, Cummins J, Pruchnic
R,Mytinger J, Cao B, Gates C, Wernig A, Huard J
Identification of a novel population of muscle stem cells in mice:
potential for muscle regeneration
J Cell Biol, 2002 May 27;157(5):851-64. PMID: 12021255 [PubMed
- indexed for MEDLINE]
Lee JY, Qu-Petersen Z, Cao B, Kimura S, Jankowski R, Cummins J, Usas
A,Gates C, Robbins P, Wernig A, Huard J
Clonal isolation of muscle-derived cells capable of enhancing muscle
regeneration and bone healing
J Cell Biol, 2000 Sep 4;150(5):1085-100. PMID: 10973997 [PubMed
- indexed for MEDLINE]
Jankowski R, Deasy B, Cao B, Gates C, Huard J
The Role of CD34 Expression and Cellular Fusion in the Regeneration
Capacity of Myogenic Progenitor Cells
J Cell Science, 2002 Nov 15; 115 (22): 4361-4374
Jordan F. Karp, M.D.
Physician-Investigator at the John A. Hartford Center of Excellence in Geriatric Psychiatry Department of Psychiatry University of Pittsburgh Medical Center Western Psychiatric Institute and Clinic
After graduating from the University of Pittsburgh School of Medicine, Dr. Karp completed a residency in psychiatry at Columbia University in New York City. He returned to Pittsburgh for a clinical fellowship in geriatric psychiatry. Now working in the division of geriatric psychiatry, Dr. Karp studies older adults with comorbid depression and persistent pain. Dr Karp has authored or co-authored 28 scientific articles and book chapters, many of them focusing on the depression/pain interface. He is currently conducting a treatment study of older adults with both major depression and chronic low back pain.
Eric Lenze, MD: Anxiety and depression intervention in geriatrics
Assistant
Professor of Psychiatry and a member of the Intervention Research Center
for Late-Life Mood Disorders (IRC/LLMD). He has experience in anxiety
and depression intervention in geriatric populations, as well as psychiatric
interventions in the medical rehabilitation setting.
Representative Articles:
Lenze EJ, Mulsant BH, Shear MK, Schulberg HC, Dew MA, Begley AE, Pollock
BG, Reynolds CF: Anxiety disorders in depressed elderly patients. American
Journal of Psychiatry 2000; 157 (5): 722-728.
Lenze EJ, Pollock BG, Shear MK, Mulsant BH, Bharucha A, Reynolds CF:
Treatment considerations for anxiety in the elderly. CNS Spectrums
2003; 8(12, Suppl 3):6-13.
Lenze EJ: Comorbidity of depression and anxiety in the elderly. Current
Psychiatry Reports 2003; 51:62-67.
Lenze EJ, Mulsant BH, Shear MK, Dew MA, Miller MD, Pollock BG, Houck
P, Tracey B, and Reynolds CF: Efficacy and tolerability of citalopram
in the treatment of late life anxiety disorders: Results from an eight-week,
placebo-controlled trial. American Journal of Psychiatry, (in press).
Lenze EJ, Mulsant BH, Mohlman J, Shear MK, Dew MA, Schulz R, Miller
MC, Tracey B, and Reynolds CF: Generalized anxiety disorder in late
life: Longitudinal course and comorbidity with Major Depressive Disorder.
American Journal of Geriatric Psychiatry, (in press).
Lynn M. Martire, PhD: Late-life
chronic illness, family caregiving, and psychosocial interventions
Representative Articles
Martire, LM, Stephens, MAP, Druley, JA, Wojno, W C (2002)
Negative reactions to received spousal care: Predictors and consequences
of miscarried support
Health Psychology, 21, 167-176.
Martire, LM, Schulz, R, Keefe, FJ, Starz, TW, Osial, TA, Dew, MA,
Reynolds, CF (2003)
Feasibility of a dyadic intervention for management of osteoarthritis:
A pilot study with older patients and their spousal caregivers
Aging and Mental Health, 7, 53-60.
Martire, LM, Schulz, R, Wrosch, C, Newsom, JT (to be published 2003,
December)
Perceptions and implications of received spousal care: Evidence from
the Caregiver Health Effects Study
Psychology and Aging
Benoit H. Mulsant, MD: Treatment of psychiatric disorders in older adults
Dr. Mulsant is currently a Professor of Psychiatry at the School of Medicine, University of Pittsburgh. He is also the Associate Director of the Geriatric Psychiatry Fellowship Program and the Medical Director of the Electroconvulsive Therapy Service at Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center. Dr. Mulsant has authored and co-authored more than 200 journal articles and book chapters and he has been listed in The Best Doctors in America since 1996. He has been and is currently a principal investigator for several federally-funded and industry-sponsored clinical research trials on psychiatric disorders in geriatric patients. Dr. Mulsant earned his MD from the School of Medicine, Laval University, Quebec; he completed his internship in internal medicine and neurology at Royal Victoria Hospital, Montreal, and Montreal Neurological Hospital, and his residency in psychiatry at Western Psychiatric Institute and Clinic, University of Pittsburgh. He is a Diplomate in Psychiatry, American Board of Psychiatry and Neurology, with added qualifications in Geriatric Psychiatry, as well as a member of the American Association for Geriatric Psychiatry, the American Psychiatric Association, the American College of Psychiatrists, and a founding member of the International College of Geriatric Psychoneuropharmacology. He is a member of the Geriatric Psychiatry Committee of the American Board of Psychiatry and Neurology and he serves on the editorial board of the American Journal of Geriatric Psychiatry; he is also a reviewer for numerous academic journals, including the Journal of the American Medical Association, American Journal of Psychiatry, Journal of American Geriatrics Society, and the International Journal of Geriatric Psychiatry.
Representative Articles
Mulsant BH, Alexopoulos GS, Reynolds CF, Katz IR, Abrams R, Oslin D, Schulberg HC (2001). Pharmacological treatment of depression in older primary care patients: the PROSPECT algorithm. International Journal of Geriatric Psychiatry, 16: 585-592
Mulsant BH, Sweet RA, Rosen J, Pollock BG, Flynn T, Begley AE, Mazumdar S, Reynolds CF (2001). A double-blind randomized comparison of nortriptyline plus perphenazine versus nortriptyline plus placebo in the treatment of psychotic depression in late life. Journal of Clinical Psychiatry, 62: 597-604
Mulsant BH, Pollock BG, Nebes R, Miller MD, Sweet RA, Stack J, Houck PR, Bensasi S, Mazumdar S, Reynolds CF (2001). A 12-week double-blind, randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatients. American Journal of Geriatric Psychiatry, 9: 406-414
Mulsant BH Pollock BG, Kirshner M, Shen C, Dodge H, Ganguli M (2003). Serum anticholinergic activity in a community-based sample of older adults. Archives of General Psychiatry, 60: 198-203
Szanto K, Mulsant BH (Corresponding Author), Houck P, Dew MA, Reynolds CF III (2003). Occurrence and course of suicidality during acute treatment of late-life depression. Archives of General Psychiatry, 60: 610-617
Bruce Pollock, PhD: Geriatric
pharmacology, especially related to psychotropic agents
Representative Articles
Pollock BG, Mulsant BH, Rosen J, Sweet RA, Mazumdar S, Bharucha A,
Marin R, Jacob NJ, Huber KA, Kastango KB, Chew ML
Comparison of citalopram, perphenazine, and placebo for the acute treatment
of psychosis and behavioral disturbances in hospitalized, demented
patients
Am J Psychiatry, 2002 Mar;159(3):460-5
PMID: 11870012 [PubMed - indexed for MEDLINE]
Murphy GM Jr, Pollock BG, Kirshner MA, Pascoe N, Cheuk W, Mulsant
BH, Reynolds CF 3rd
CYP2D6 genotyping with oligonucleotide microarrays and nortriptyline
concentrations in geriatric depression
Neuropsychopharmacology, 2001 Nov;25(5):737-43.
PMID: 11682257 [PubMed - indexed for MEDLINE]
Pollock BG, Ferrell RE, Mulsant BH, Mazumdar S, Miller M, Sweet RA,
Davis S, Kirshner MA, Houck PR, Stack JA, Reynolds CF, Kupfer DJ
Allelic variation in the serotonin transporter promoter affects onset
of paroxetine treatment response in late-life depression
Neuropsychopharmacology, 2000 Nov;23(5):587-90.
PMID: 11027924 [PubMed - indexed for MEDLINE]
Connie Tompkins, PhD: Cognitive underpinnings of neurologic communication disorders
Representative Articles
Tompkins, CA, Fassbinder, W, Lehman-Blake, MT and Baumgaertner, A
(2002)
The nature and implications of right hemisphere language disorders:
Issues in search of answers
In A. Hillis (Ed.), Handbook of adult language disorders: Integrating
cognitive neuropsychology, neurology, and rehabilitation (pp. 429-448)
Psychology Press
Tompkins, CA, Lehman-Blake, MT (2003)
Language disorders
In D.J. Ekerdt et al. (Eds.),
Macmillan Encyclopedia of Aging, Vol. III (pp. 764-767); New York:
Macmillan Reference USA.
Tompkins, CA, Fassbinder, W (in press)
Right hemisphere language disorders
In R. Kent (Ed.),
MIT Encyclopedia of Communication Sciences and Disorders
MIT Press
George Zubenko, PhD: Geriatric depression; Alzheimer’s Disease
Representative Articles
Zubenko GS, ZubenkoWN, McPherson S, Spoor E, Marin DB, Farlow MR,
Smith GE, Geda YE, Cummings JL, Petersen RC, Sunderland T
A collaborative study of the emergence and clinical features of the
major depressive syndrome of Alzheimer's disease
Am J. Psychiatry, 160(5):857-66, 2003; lead article in this
month's AJP with editorial
Zubenko GS, Stiffler JS, Hughes HB, Fatigati MJ, Zubenko WN
Genome survey for loci that influence successful aging: Sample characterization,
method validation, and initial results for the Y chromosome
Am. J. Geriatr. Psychiatry, 10(5):619-630, 2002.
Zubenko GS, Hughes HB, Stiffler JS
D10S1423 identifies a susceptibility locus for Alzheimer's disease
in a prospective, longitudinal, double-blind study of asymptomatic
individuals
Mol. Psychiatry, 6:413-419, 2001
Zubenko GS, Sunderland, T
Geriatric Psychopharmacology: Why Does Age Matter?
Harv. Rev. Psychiatry, I:311-333, 2000
Zubenko GS
Do susceptibility loci contribute to the expression of more than one
mental disorder? A view from the genetics of Alzheimer's disease
(Millennium Article)
Mol. Psychiatry, 5(2):131-136, 2000
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