Researchers

University of Pittsburgh Council on Aging Members

Charles F. Reynolds III, M.D. is the UPMC Professor of Geriatric Psychiatry; and professor of neurology and neuroscience; Senior Associate Dean University of Pittsburgh School of Medicine; and professor of behavioral and community health sciences at the University of Pittsburgh Graduate School of Public Health. The recipient of a National Institute of Mental Health (NIMH) Research Scientist Award and a MERIT award for studies of "Maintenance Therapies in Late Life Depression," Dr. Reynolds has twice been named one of The Best Doctors in America and has received the Exemplary Psychiatrist Award from the National Alliance for the Mentally Ill. Dr. Reynolds chaired the 2001 consensus conference on Unmet Needs in the Diagnosis and Treatment of Late-Life Mood Disorders, sponsored by the National Depressive and Manic Depressive Association. Dr. Reynolds has served as a member of two Institute of Medicine study panels ("Reducing Suicide: A National Imperative"; and "Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem"), as a member of the National Advisory Mental Health Council of the NIMH, and as President of the American College of Psychiatrists and of the International College of Geriatric Psychoneuropharmacology." Dr. Reynolds serves as director and principal investigator of the NIMH-sponsored Advanced Center for Interventions and Services Research in Late Life Mood Disorders and the John A. Hartford Center of Excellence in Geriatric Psychiatry, where he and his colleagues conduct treatment research to help elderly patients living with depression and other mood disorders. The themes of his research program encompass prevention of depression, and its complications (such as suicide) in elderly at high risk, treatment of elderly with severe mood disorders, and identification and removal of barriers to depression treatment in community settings. Dr. Reynolds’ community partners include Community Medicine, Inc. of the UPMC, Coordinated Care Network, and the Mental Health Association of Allegheny County. Dr. Reynolds also directs research training in mental health and aging at WPIC and serves as research training director in project EXPORT HEALTH at the Pitt Graduate School of Public Health, a program dedicated to reducing health disparities in African Americans. Together with Mark Miller, M.D., Dr. Reynolds published in 2002 (Johns Hopkins University Press) Living Longer Depression Free, a guide for elderly depressed patients and their family caregivers. Dr. Reynolds' bibliography contains over 475 publications in peer reviewed journals, including papers in the Journal of the American Medical Association and the New England Journal of Medicine. He is currently associate editor of the American Journal of Geriatric Psychiatry and has previously served on the editorial boards of the American Journal of Psychiatry and of Neuropsychopharmacology.

Research Areas of Interest: depression in older adults

Representative Articles

Reynolds CF, 3rd, Dew MA, Pollock BG, et al. Maintenance treatment of major depression in old age. New England Journal Medicine, Mar 16 2006; 354(11):1130-1138.

Reynolds CF, Frank E, Perel JM, et al. Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: A randomized controlled trial in patients older than 59 years. Journal of the American Medical Association, 1999;281(1):39-45.

Reynolds CF, Miller MD, Pasternak RE, et al. Treatment of bereavement-related major depressive episodes in later life: A controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapy. American Journal of Psychiatry, 1999;156(2):202-208.

Reynolds CF, Perel JM, Frank E, et al. Three year outcomes of maintenance nortriptyline treatment in late-life depression: A study of two fixed plasma levels.
American Journal of Psychiatry, 1999;156(8):1177-1181.

Charney DS, Reynolds CF, Lewis L, et al. Depression and bipolar support alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life. Archives of General Psychiatry, 2003;60:664-672.

Bruce ML, Ten Have TR, Reynolds CF, et al. Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: A randomized controlled trial. Journal of the American Medical Association, 291(9):1081-1090, 2004.

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